The mammalian gut has a remarkable abundance of microbes. These microbes have strong potential to biosynthesize distinct metabolites that are promising drugs, and many more bioactive compounds have yet to be explored as potential drug candidates. These small bioactive molecules often mediate important host–microbe and microbe–microbe interactions. In this review, we provide perspectives on and challenges associated with three mining strategies – culture-based, (meta)genomics-based, and metabolomics-based mining approaches – for discovering natural products derived from biosynthetic gene clusters (BGCs) in mammalian gut microbiota.
Source: Bio Technology